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Salt induces hepatic inflammatory response through epigenetic modulation of SIRT3 [Bisulfite-seq]

ABSTRACT: Purpose: Our previous study has confirmed that reduction of SIRT3 expression is a main factor contributing to salt-induced hepatic inflammtion. Here we sought to investigate whether salt-induced SIRT3 reduction was related to epigenetic modification. Methods: 6-week-old male wild-type mice were fed with high salt diet (HSD, containing 8% NaCl) or normal salt diet (NSD, containing 0.4% NaCl) for 4 months. And then their liver tissues were removed and subjected to bilsulfate-seq. Results: Through bisulfate-seq, we did not observe any change in DNA methylation in the CpG island of Sirt3 gene promoter region. Conclusions: Salt-induced SIRT3 reduction is not related to DNA methylation on SIRT3 gene promoter.

ORGANISM(S): Mus musculus

PROVIDER: GSE183583 | GEO | 2023/09/01

REPOSITORIES: GEO

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Salt induces hepatic inflammatory response through epigenetic modulation of SIRT3 [RNA-seq]

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2023-09-01 | GSE183584 | GEO

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2011-03-15 | E-GEOD-27309 | biostudies-arrayexpress

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