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Transcriptome analysis of whole lung tissue from anti-PD-1 therapy-treated mice

ABSTRACT: IIn contrast to the young mice treated with anti-PD-1 therapy, aged mice exhibited immune-related adverse event (irAE)-like symptoms in the lung when treated with anti-PD-1 therapy. To understand the molecular events underlying the development of anti-PD-1 therapy-induced irAE, we employed deep RNA sequencing of whole lung transcript from anti-PD-1 therapy-treated young and aged mice. In order to further evaluate the effect of IL-21 signal on PD-1-blockade-mediated immune response, gene expression profile in lung tissue from aged mice twith the blockade of IL-21 activity was also assessed.

ORGANISM(S): Mus musculus

PROVIDER: GSE184000 | GEO | 2022/05/30

REPOSITORIES: GEO

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