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RNAseq anaysis of hippocamal parvalbumin-positive interneurons in mice exposed to chronic social defat stress

ABSTRACT: Purpose: To identify genes differentially expressed in parvalbumin-positive (PV) interneurons of the hippocampus in non-defetaed (CTRL), stress-susceptible and stress-resilient mice. Method: Translating Ribosome Affinity Purification (TRAP) to isolate RNA from PV+ cells, cDNA synthesis and next generation RNAseq using Illumina Nextseq 500 sequencer. Results: RNA-seq revealed 458 DEGs between non-defeated and resilient mice, 1976 DEGs in non-defeated and susceptible mice, and 3475 DEGs in resilient and susceptible mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE184027 | GEO | 2021/09/14

REPOSITORIES: GEO

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