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Functional study of Rbbp5 in preimplantation embryos

ABSTRACT: We performed RNA-sequencing, ChIP-sequncing and Brif-sequencing on Rbbp5 knockout (KO) and wild-type (WT) mouse ICM and E5.0 epiblast. Our results showed that Rbbp5 KO lead to significant reduction of H3K4me3 modification at early blastocyst stage. The change in H3K4me3 landscape occured before the transcriptome change. Moreover, Rbbp5 KO specifically affected epiblast lineages the most at late blastocyst stage and the KO embryos died at E5.5.

ORGANISM(S): Mus musculus

PROVIDER: GSE184166 | GEO | 2022/12/30

REPOSITORIES: GEO

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