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Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation

ABSTRACT: In the present studies we identified NTPDase8 a top downregulated gene in the liver of mice submitted to the cecal ligation-induced sepsis. Immunohistochemical analysis confirmed the decrease on NTPDase8 expression at the protein level. In vitro mechanistic studies using HepG2 hepatoma cells demonstrated that IL-6 but not TNF, IL-1b, bacteria or lipopolysaccharide are able to suppress NTPDase8 gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE184167 | GEO | 2021/09/18

REPOSITORIES: GEO

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Host Responses to Sepsis Vary in Different Low-Lethality Murine Models

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