Transcriptomics

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Transcriptome profiling of Drosophila adults from multiple generations including flies with genetically-ablated insulin-producing cells as founders.


ABSTRACT: Transgenerational epigenetic inheritance is a subject of immense current interest. In a newly developed Drosophila model in the laboratory, genetic ablation of insulin-producing cells (IPCs) was found to affect whole -body triglyceride levels not only in the ablated flies but also in their male-line derived, non-ablated future generations. To further characterize this genetic-factor-induced transgenerational inheritance model, we have now performed whole body microarray gene expression profiling of adult males and females with genetically ablated IPCs, and of three consecutive, paternally derived non-ablated generations of adult males and females originating from ablated males. Interestingly, like altered levels of triglycerides, transcriptomic alterations are found not only in the ablated flies but also in their male-line-derived, non-ablated future generations.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE184339 | GEO | 2023/04/21

REPOSITORIES: GEO

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