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Cell and sub-compartment specific proteomics reveals astrocyte contributions in a mouse model of OCD

ABSTRACT: We investigated the sub-proteomes of different functional compartments in astrocyte and neurons in the striatum. We compared the proteomes to the cell-specific RNA profiles of neurons and astrocytes from these analyses. We found one gene and protein that was highly expressed in neurons and astrocytes called SAPAP3. Knockout of this gene product results in an OCD-like phenotype in mouse. RNA-seq of astrocytes and bulk RNA-seq analyses of this mouse model revealed very low DEGs.

ORGANISM(S): Mus musculus

PROVIDER: GSE184773 | GEO | 2023/01/13

REPOSITORIES: GEO

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Astrocyte and neuron subcompartment proteomes reveal distinct cellular and molecular mechanisms of OCD

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