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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE184801 | GEO | 2021/09/27

REPOSITORIES: GEO

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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.

Project description:Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured sensory neurons as a mechanism contributing to nerve injury-induced pain. Here, we show that intrathecal administration of CSF1, even in the absence of injury, is sufficient to induce pain behavior, but only in male mice. Transcriptional profiling and morphologic analyses after intrathecal CSF1 showed robust immune activation in male but not female microglia. CSF1 also induced marked expansion of lymphocytes within the spinal cord meninges, with preferential expansion of regulatory T-cells (Tregs) in female mice. Consistent with the hypothesis that Tregs actively suppress microglial activation in females, Treg deficient (Foxp3DTR) female mice showed increased CSF1-induced microglial activation and pain hypersensitivity equivalent to males. We conclude that sexual dimorphism in the contribution of microglia to pain results from Treg-mediated suppression of microglial activation and pain hypersensitivity in female mice.

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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp2]

Project description:RNA-sequencing data of female lumbar dorsal horn spinal cord microglia from WT or Treg KO mice after 3 days of CSF1 i.t. injection.

2021-09-27 | GSE184800 | GEO

Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp1]

Project description:RNA-sequencing data of male and female lumbar dorsal horn spinal cord microglia after 3 days of CSF1 or saline i.t. injection.

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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

Project description:Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp2]

Project description:Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp2]

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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp1]

Project description:Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp1]

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HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

Project description:A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.

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Injury-induced enhancer remodelling in spinal microglia - a novel mechanism for pain chronification?

Project description:This SuperSeries is composed of the SubSeries listed below.

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HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

Project description:This SuperSeries is composed of the SubSeries listed below.

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