Other

Dataset Information

0

NDF Is a Transcription Factor that Stimulates Elongation by RNA Polymerase II


ABSTRACT: RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we find that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than does transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II-binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.

ORGANISM(S): Homo sapiens

PROVIDER: GSE185464 | GEO | 2022/03/10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-07-15 | PXD024457 | Pride
2023-10-11 | PXD045446 | Pride
2013-09-23 | E-MTAB-1894 | biostudies-arrayexpress
2018-11-30 | GSE120201 | GEO
2018-10-22 | PXD008223 | Pride
2013-04-10 | E-GEOD-41323 | biostudies-arrayexpress
2013-04-10 | E-GEOD-41324 | biostudies-arrayexpress
2013-04-10 | GSE41324 | GEO
2013-04-10 | GSE41323 | GEO
2012-06-29 | E-MTAB-1060 | biostudies-arrayexpress