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Low dose human chorionic gonadotropin hCG

ABSTRACT: Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. In addition, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, we want to study the implantation potential. Keywords: gene expression analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE18557 | GEO | 2010/10/02

SECONDARY ACCESSION(S): PRJNA121373

REPOSITORIES: GEO

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Low dose human chorionic gonadotropin hCG

Project description:Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. In addition, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, we want to study the implantation potential. Keywords: gene expression analysis In total 10 samples from patients without pregnancy following embryo transfer were analyzed for gene expression analysis with microarrays, 5 patients from group A (rFSH group) and 5 patients from group B (hCG group) were compared

2010-10-02 | E-GEOD-18557 | biostudies-arrayexpress

Low dose hCG pregnant vs non-pregnant

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Low dose hCG pregnant vs non-pregnant

Project description:Influence of ovarian stimulation with 200 IU of hCG, (administered in the late follicular phase among ICSI patients undergoing a GnRH-antagonist protocol), on the endometrium on the day of oocyte pick-up. The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. In addition, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, we want to study the implantation potential. Pregnant and non-pregnant patients were compared. In total 6 samples were analyzed for gene expression analysis with microarrays, 3 pregnant and 3 non-pregnant patients were compared.

2010-09-07 | E-GEOD-21225 | biostudies-arrayexpress

Transcription profiling of rat ovaries after 48 h of drug treatments.S1)1 IU PMSG + 1 IU hCG (this is the control)S2) 10 IU PMSG + 10 IU hCGS3) 40 IU PMSG + 30 IU hCG

Project description:the aim of this work is to gain insight into Ovarianhyperstimulation Syndrome. All samples were mRNA from rat ovaries after 48 h of drug treatments.S1)1 IU PMSG + 1 IU hCG (this is the control)S2) 10 IU PMSG + 10 IU hCGS3) 40 IU PMSG + 30 IU hCG

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Project description:The objective of this experiment was to explore differences in follicle transcriptomes in patients having oocyte maturation induced with either a bolus of hCG or a GnRH agonist. Upon oocyte retrieval, mural granuloasa cells and cumulus cells were isolated, allowing for comparison of the follicular transcriptomes between patients treated with eihter hCG or the GnHR agonist.

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Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction.

Project description: Not available

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Human chorionic gonadotropin modulates the transcriptome of the myometrium and cervix in late gestation

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Chemical synthesis of the ?-subunit of human luteinizing (hLH) and chorionic gonadotropin (hCG) glycoprotein hormones.

Project description:Human luteinizing hormone (hLH) and human chorionic gonadotropin (hCG) are human glycoprotein hormones each consisting of two subunits, an identical ?-subunit and a unique ?-subunit, that form noncovalent heterodimers. Structurally, ?-hCG shares a high degree of sequence similarity with ?-hLH, including a common N-glycosylation site at the N-terminus but differs mainly in the presence of an extended C-terminal portion incorporating four closely spaced O-linked glycans. These glycoproteins play important roles in reproduction and are used clinically in the treatment of infertility. In addition, the role of hCG as a tumor marker in a variety of cancers has also attracted significant interest for the development of cancer vaccines. In clinical applications, these hormones are administered as mixtures of glycoforms due to limitations of biological methods in producing homogeneous samples of these glycoproteins. Using the powerful tools of chemical synthesis, the work presented herein focuses on the highly convergent syntheses of homogeneous ?-hLH and ?-hCG bearing model glycans at all native glycosylation sites. Key steps in these syntheses include a successful double Lansbury glycosylation en route to the N-terminal fragment of ?-hCG and the sequential installation of four O-linked glycosyl-amino acid cassettes into closely spaced O-glycosylation sites in a single, high-yielding solid-supported synthesis to access the C-terminal portion of the molecule. The final assembly of the individual glycopeptide fragments involved a stepwise native chemical ligation strategy to provide the longest and most complex human glycoprotein hormone (?-hCG) as well as its closely related homologue (?-hLH) as discrete glycoforms.

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A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCG? Expression and Cell Differentiation.

Project description:Human chorionic gonadotropin (hCG) is composed of a common ? subunit and a placenta-specific ? subunit. Importantly, hCG is highly expressed in the differentiated and multinucleated syncytiotrophoblast, which is formed via trophoblast cell fusion and stimulated by cyclic AMP (cAMP). Although the ubiquitous activating protein 2 (AP2) transcription factors TFAP2A and TFAP2C may regulate hCG? expression, it remains unclear how cAMP stimulates placenta-specific hCG? gene expression and trophoblastic differentiation. Here we demonstrated that the placental transcription factor glial cells missing 1 (GCM1) binds to a highly conserved promoter region in all six hCG? paralogues by chromatin immunoprecipitation-on-chip (ChIP-chip) analyses. We further showed that cAMP stimulates GCM1 and the CBP coactivator to activate the hCG? promoter through a GCM1-binding site (GBS1), which also constitutes a previously identified AP2 site. Given that TFAP2C may compete with GCM1 for GBS1, cAMP enhances the association between the hCG? promoter and GCM1 but not TFAP2C. Indeed, the hCG-cAMP-protein kinase A (PKA) signaling pathway also stimulates Ser269 and Ser275 phosphorylation of GCM1, which recruits CBP to mediate GCM1 acetylation and stabilization. Consequently, hCG stimulates the expression of GCM1 target genes, including the fusogenic protein syncytin-1, to promote placental cell fusion. Our study reveals a positive feedback loop between GCM1 and hCG regulating placental hCG? expression and cell differentiation.

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