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CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

ABSTRACT: Purpose: Metastasis are responsible for the most majority of cancer-related deaths due to the lack of effective targeted therapies. Therefore, specific targets which tackle that complex process are needed to improve the therapeutic outcomes of metastatic breast cancer. Methods: ATAC-Seq analysis of CECR2 knockout and control LM2 cells. Results: CECR2 knockout regulate chromatin accessibility of NF-kB target genes . Conclusions: Our work confirmed that CECR2 knockout attenuates chromatin accessibility at promoters or enhancers of the downstream NF-kB target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE185647 | GEO | 2022/01/21

REPOSITORIES: GEO

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Acetyl-lysine Reader CECR2 Drives Breast Cancer Metastasis by Coordinating Macrophage Polarization and Immune Suppression [metastasis]

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CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

Project description:CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

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