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Molecular Pathways are influenced by Progranulin in a neuronal cell model

ABSTRACT: Gene expression microarrays were used to identify how the mRNA phenotype of NSC-34 cells responds to PGRN expression levels. PGRN expression correlated well with molecular phenotypes that included mRNA pathways associated with the regulation of the cytoskeleton Gene expression profile was determined using Illumina Mouse Whole-Genome Expression BeadChips (MouseWG-6 v2.0

ORGANISM(S): Mus musculus

PROVIDER: GSE185877 | GEO | 2021/10/14

REPOSITORIES: GEO

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Multiple Molecular Pathways are influenced by Progranulin in a neuronal cell model

Project description:NSC-34 cells produced by fusing mouse embryonic spinal cord motor neuron with neuroblastoma cells expressing reduced level of PGRN (NSC-34/ShPGRN), NSC-34 cells overexpressing hPGRN(NSC-34-/hPGRN) or vector controls were compared in triplicate

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Progranulin A mediated MET signalling is essential for liver morphogenesis in zebrafish

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Progranulin A mediated MET signalling is essential for liver morphogenesis in zebrafish

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