Three-dimensional analysis of genome organization in CTCF-WT and CTCF-KO dendritic cells (HiC)

ABSTRACT: Purpose: The goals of this study are to analyze global transcriptional, epigenetic and topological changes in dendritic cells under LPS treatment condition and to investigate how CTCF regulates three-dimensional chromatin interaction in inflammatory response. Conclusions: Our study provides the detailed analysis of transcriptional, epigenetic and topological genome profiles in mouse dendritic cells under LPS treatment condition. Moreover, our data show how three-dimensional enhancer networks control gene expression during DC activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE185882 | GEO | 2023/01/04

REPOSITORIES: GEO