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Pseudomonas aeruginosa gene regulation by Staphylococcus aureus supernatant or added secreted products

ABSTRACT: Pseudomonas aeruginosa and Staphylococcus aureus are often co-isolated in persistent infections. The goal of this study was to determine how secreted products that were identified in S. aureus supernatant affect gene expression in P. aeruginosa. Therefore, media control, the indicated products in media, or S. aureus supernatant was added to P. aeruginosa cultures at 25% total volume and gene expression was measured at 20 min and 2 h using RNA-seq. The individual products induced distinct pathways in P. aeruginosa. The products in combination recapitulated much of the differential gene expression seen in P. aeruginosa in response to S. aureus supernatant.

ORGANISM(S): Pseudomonas aeruginosa PA14

PROVIDER: GSE186138 | GEO | 2022/05/18

REPOSITORIES: GEO

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