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Transcriptional profiling reveals an upregulation of genes related to Sphingolipid metabolism and Oxidative phosphorilation in HRas and NRas double-KO mice (DKO), which die because of a severe respiratory distress

ABSTRACT: We used microarrays to investigate gene expression changes in the lungs of Control, Hras-KO, Nras-KO and DKO mice. These DKO animals die at birth because of respiratory distress, caused by an impaired lung maturation. N-acetyl cysteine antenatal treatment ameliorates the newborn lethality.

ORGANISM(S): Mus musculus

PROVIDER: GSE186161 | GEO | 2021/10/22

REPOSITORIES: GEO

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