Transcriptomics

Dataset Information

0

Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation


ABSTRACT: The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment of T3, the active form of TH, increases the recruitment of thermogenic capacity in interscapular BAT of male mice through hyperplasia by promoting the TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals the heterogeneous nature and hierarchical trajectory within adipocyte progenitor cellsof interscapular BAT. Further analyses suggest that T3 facilitates cell state transition from a more stem-like state towards a more committed adipogenic state and promotes cell cycle progression towards a mitotic state in adipocyte progenitor cells, through mechanisms involving the action of Myc on glycolysis. Our findings elucidate the mechanisms underlying the TH action in adipocyte progenitors residing in BAT and provide a framework for better understanding of the TH effects on hyperplastic growth and adaptive thermogenesis in BAT depot at a single-cell level.

ORGANISM(S): Mus musculus

PROVIDER: GSE186188 | GEO | 2022/05/13

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-07-26 | GSE199998 | GEO
2014-12-31 | GSE58062 | GEO
| PRJNA772797 | ENA
2011-10-31 | GSE32443 | GEO
2011-10-31 | GSE32444 | GEO
2011-10-31 | E-GEOD-32443 | biostudies-arrayexpress
2011-10-31 | E-GEOD-32444 | biostudies-arrayexpress
2017-11-10 | GSE96679 | GEO
2022-04-29 | GSE201135 | GEO
2021-06-16 | E-MTAB-8717 | biostudies-arrayexpress