Dynamic genome-wide interaction patterns elucidate the roles of Ki67 in chromatin organization

ABSTRACT: Ki67 is a widely-used proliferation marker with functions in chromosomal organization. It forms a protective layer around mitotic chromosomes and is involved in genome positioning in interphase. However, a detailed understanding of how Ki67 organizes the genome was still lacking, partially because genome-wide interaction profiles were missing. Here, we generate DNA-Ki67 interaction profiles using our pA-DamID method, and show that Ki67 interacts with the genome in a domain-like pattern that partially overlaps with lamina-associated domains.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186206 | GEO | 2021/10/20

REPOSITORIES: GEO