Transcriptomics

Dataset Information

0

Therapeutic Effect of Histone Acetyltransferase Inhibitors on Galactose-Induced Cataract in Rats


ABSTRACT: We investigated the therapeutic effects of histone acetyltransferase (HAT) inhibitors on cataracts using an ex vivo model of galactose-induced cataracts in the rat lens.Among the tested HAT inhibitors, TH1834 was the only inhibitor that could completely reverse white opacities once formed in the lens. Combination treatment with C646/CPTH2 and CBP30/CPTH2 also had therapeutic effects. To identify the genes regulated by HAT inhibitors, we conducted microarray analysis of treated and untreated cataract samples.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE186248 | GEO | 2022/12/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-09-24 | GSE194074 | GEO
| PRJNA773070 | ENA
2021-12-23 | GSE185143 | GEO
| PRJNA925806 | ENA
2015-05-01 | E-GEOD-65500 | biostudies-arrayexpress
| PRJNA799010 | ENA
2023-11-18 | GSE223322 | GEO
2015-05-01 | GSE65500 | GEO
2021-03-10 | GSE157061 | GEO
2020-03-04 | GSE135000 | GEO