Therapeutic Effect of Histone Acetyltransferase Inhibitors on Galactose-Induced Cataract in Rats
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ABSTRACT: We investigated the therapeutic effects of histone acetyltransferase (HAT) inhibitors on cataracts using an ex vivo model of galactose-induced cataracts in the rat lens.Among the tested HAT inhibitors, TH1834 was the only inhibitor that could completely reverse white opacities once formed in the lens. Combination treatment with C646/CPTH2 and CBP30/CPTH2 also had therapeutic effects. To identify the genes regulated by HAT inhibitors, we conducted microarray analysis of treated and untreated cataract samples.
ORGANISM(S): Rattus norvegicus
PROVIDER: GSE186248 | GEO | 2022/12/11
REPOSITORIES: GEO
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