Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATACseq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8

ABSTRACT: Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

ORGANISM(S): Homo sapiens

PROVIDER: GSE186623 | GEO | 2022/07/20

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ChIP-seq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2023-12-17 | GSE163676 | GEO

CUT&TAG seq analysis of HEK cells transfected with SARS-CoV-2 protein Orf8

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE186624 | GEO

ATACseq analysis of A549 cells infected with SARS-CoV-2

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE186621 | GEO

Viral mimicry of Interleukin-17A by SARS-COV-2 ORF8

Project description:SARS-CoV-2 infection triggers cytokine-mediated inflammation, leading to a myriad of clinical presentations in COVID19. The SARS-CoV-2 ORF8 is a secreted and rapidly evolving glycoprotein. Patients infected with SARS-CoV-2 ORF8-deleted variants are associated with mild disease outcomes, but the molecular mechanism this behind is unknown. Here, we report that SARS-CoV-2 ORF8 is a viral cytokine that is similar but distinct from interleukin 17A (IL-17A) as it induces stronger and broader human IL-17 receptor (hIL-17R) signaling than IL-17A. ORF8 primarily targeted blood monocytes and induced the heterodimerization of hIL-17RA and hIL-17RC, triggering robust inflammatory response. Transcriptome analysis revealed that besides its activation of the hIL-17R pathway, ORF8 upregulated gene expressions for fibrosis signaling and coagulation dysregulation. A naturally occurring ORF8 L84S variant that highly associated with mild COVID-19 showed reduced hIL-17RA binding and attenuated inflammatory responses. This study discovers SARS-CoV-2 ORF8 as a viral mimicry of IL-17 cytokine to contribute COVID-19 severe inflammation.

2022-03-11 | GSE196455 | GEO

ATACseq analysis of A549 cells infected with SARS-CoV-2 with dARKSAP virus Set 3

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE205620 | GEO

ATACseq analysis of A549 cells infected with SARS-CoV-2 with dARKSAP virus Set 2

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE205619 | GEO

RNAseq analysis of HEK293T expressing GFP, Orf8, or Orf8 with an ARKSAP deletion

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE186625 | GEO

RNAseq analysis of SARS-CoV-2 infection of iAT2 cells

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE186627 | GEO

RNAseq analysis of SARS-CoV-2 infection of A549ACE cells

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE186622 | GEO

RNAseq analysis of SARS-CoV-2 infection of A549ACE cells with dARKSAP virus

Project description:Analysis of histone mimicry by SARS-CoV-2 Orf8 encoded protein

2022-07-20 | GSE205621 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data