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Epigenetic profiling of microglia-specific gene transcription and chromatin accessibility in mouse forebrain after chronic mild stress

ABSTRACT: Multiple studies have suggested that stress induces neuroinflammation and contributes to emotion-related behavioral deficits. To study epigenetic changes in microglia after chronic stress, we purified microglia from mouse brain after exposure to chronic unexpected mild stress (CUMS), and then performed RNA-seq and ATAC-seq to study microglia-specific alterations of transcriptome and chromatin accessibility in response to chronic stress.

ORGANISM(S): Mus musculus

PROVIDER: GSE186760 | GEO | 2022/12/31

REPOSITORIES: GEO

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