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Downregulation of HDAC9 by β-hydroxybutyrate suppresses vascular calcification in chronic kidney disease

ABSTRACT: In this study, we report the protective effect of β-hydroxybutyrate (BHB) on vascular calcification in chronic kidney disease (CKD). To further investigate the mechanism underpinning the protective effect of BHB on vascular calcification, we performed high-throughput RNA-seq to identify the target gene of BHB. Our data demonstrate that BHB supplementation inhibits vascular calcification in CKD via targeting HDAC9.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186772 | GEO | 2021/11/01

REPOSITORIES: GEO

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Downregulation of HDAC9 by β-hydroxybutyrate suppresses vascular calcification in chronic kidney disease

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