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Integrative Multi‑omics Analysis Reveals Candidate Biomarkers for Oral Squamous Cell Carcinoma

ABSTRACT: We analyzed differentially expressed genes (DEGs) associated with OSCC using RNA sequencing technology. Methylation‑regulated and differentially expressed genes (MeDEGs) of OSCC were further identified via an integrative approach by examining methylomic datasets together with our own transcriptomic data. Protein‑protein interaction (PPI) networks of MeDEGs were constructed and highly connected hub MeDEGs were identified from these PPI networks. A total of 56 upregulated MeDEGs and 170 downregulated MeDEGs were identified in OSCC. Eleven hub genes with high degree of connectivity were picked out from the protein‑protein interaction (PPI) networks constructed by those MeDEGs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186775 | GEO | 2022/10/31

REPOSITORIES: GEO

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