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Genome-Wide Host Methylation Profiling of Anal and Cervical Carcinoma [anal]

ABSTRACT: HPV infection results in changes in host gene methylation which, in turn, are thought to contribute to the neoplastic progression of HPV-associated cancers. The objective of this study was to identify joint and disease-specific genome-wide methylation changes in anal and cervical cancer as well as changes in high-grade pre-neoplastic lesions. Formalin-fixed paraffin-embedded (FFPE) anal tissues (n=143; 99% HPV+) and fresh frozen cervical tissues (n=28; 100% HPV+) underwent microdissection, DNA extraction, HPV genotyping, bisulfite modification, DNA restoration (FFPE) and analysis by the Illumina HumanMethylation450 Array.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186858 | GEO | 2021/11/29

REPOSITORIES: GEO

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