Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sham and MI heart transcriptome after 6-week-long light-phase intermittent prednisone or vehicle administration

ABSTRACT: Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to their time of intake. Here we investigated the transcriptional effects of prednisone in heart when pulsed as intermittent once-weekly 1mg/kg i.p. dose in WT mice at ZT0 at 2-weeks after sham or myocardial infarction (MI; permanent ligation) surgeries. Aftter 6 weeks of treatment, we performed RNA-seq analysis in myocardial tissue to quantitate gene expression at isoform level.

ORGANISM(S): Mus musculus

PROVIDER: GSE186875 | GEO | 2022/06/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific KLF15 ablation

Project description:this dataset encompasses the cardiac transcriptomic changes elicited in myocardial tissues of 4months-old mice at 4 hours after a single ZT0 prednisone (1mg/kg i.p.) injection, or vehicle, in cardiomyocyte-KLF15-WT versus cardiomyocyte-KLF15-KO conditions (inducible, tamoxifen-driven ablation right prior to drug pulse).

2024-01-13 | GSE252857 | GEO

Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific GR ablation

Project description:this dataset encompasses the cardiac transcriptomic changes elicited in myocardial tissues of 4months-old male mice at 4 hours after a single ZT0 prednisone (1mg/kg i.p.) injection, or vehicle, in cardiomyocyte-GR-WT versus cardiomyocyte-GR-KO conditions (inducible, tamoxifen-driven ablation right prior to drug pulse).

2024-01-13 | GSE252826 | GEO

Myocardial GR epigenomic changes with single ZT0 prednisone pulse

Project description:this dataset encompasses the cardiac GR epigenomic changes elicited in 4-month-old mice with a single ZT0 prednisone (1mg/kg i.p.) injection

2024-01-14 | GSE252856 | GEO

Myocardial KLF15 epigenomic changes with single ZT0 prednisone pulse

Project description:this dataset encompasses the cardiac KLF15 epigenomic changes elicited in 4-month-old mice with a single ZT0 prednisone (1mg/kg i.p.) injection

2024-01-31 | GSE254114 | GEO

muscle and white adipose tissue transcriptomes in obese WT mice after 12 weeks of prednisone regimens

Project description:Exogenous glucocorticoids regulate the muscl-fat axis communication, but little attention is paid to their frequency of intake. Here we investigated the transcriptional effects of prednisone in muscle and adipose tissue when dosed as intermittent once-weekly 1mg/kg i.p. versus once-daily 1mg/kg in WT obese mice. Prior to treatment, mice were fed a high-fat diet for 12 weeks. After 12 weeks of treatment, we performed RNA-seq analysis in muscle (quadriceps) and white adipose tissue (ventral fat pad) to quantitate gene expression at isoform level.

2022-03-01 | GSE189774 | GEO

muscle transcriptional changes with once-weekly prednisone at 4- vs 24-months of age

Project description:this dataset encompasses the muscle transcriptomic changes elicited in quadriceps muscles of 4- vs 24-month-old mice (males + females) with a 12-week-long regimen of once-weekly ZT0 prednisone (1mg/kg i.p.)

2023-11-08 | GSE245227 | GEO

Muscle epigenomic changes with once-weekly prednisone at 4- vs 24-months of age

Project description:this dataset encompasses the muscle GR epigenomic changes elicited in quadriceps muscles of 4- vs 24-month-old mice (males + females) with a 12-week-long regimen of once-weekly ZT0 prednisone (1mg/kg i.p.)

2023-11-08 | GSE245493 | GEO

Muscle GR and BMAL1 epigenomic binding at ZT4 after vehicle versus prednisone pulse at ZT0

Project description:Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to their time of intake. Here we investigated the epigenetic effects of prednisone in muscle when pulsed as single 1mg/kg i.p. dose in mice WT mice at ZT0, i.e. when endogenous corticosterone is low. At 4-hours post-injection (ZT4), we performed ChIP-seq analysis in muscle tissue for the glucocorticoid receptor (GR), as well as BMAL1, clock factor active in the light-phase. We also performed ChIP-seq for RNApol-II to quantitate changes in RNApol-II recruitment. We repeated the GR and RNApol-II analyses in muscles from BMAL1-knockout mice.

2022-02-18 | GSE186438 | GEO

sham and MI heart transcriptome after 6-week-long light-phase intermittent prednisone or vehicle administration

Project description:sham and MI heart transcriptome after 6-week-long light-phase intermittent prednisone or vehicle administration

| PRJNA776628 | ENA

Muscle GR and BMAL1 epigenomic binding at ZT4 after vehicle versus prednisone pulse at ZT0

Project description:Muscle GR and BMAL1 epigenomic binding at ZT4 after vehicle versus prednisone pulse at ZT0

| PRJNA773794 | ENA