Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomes of 8 radiosensitive and 8 radioresistant colorectal cancer (CRC) patients

ABSTRACT: Radiotherapy is essential to treat colorectal cancer (CRC) although the tolerance of which is of quite common occurrence in clinic. Long noncoding RNA (lncRNA) and circular RNA (circRNAs) have an important role in the radio-resistance of CRC through regulating targeted genes or proteins expression at either transcriptional or post-translational levels. In this study, we aimed to seek out novel lncRNAs and circRNAs involved in radio-resistance by RNA-seq analysis of 8 radiosensitive and 8 radioresistant CRC patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186940 | GEO | 2021/11/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling of human radioresistant and radiosensitive tumors and cell lines

Project description:This SuperSeries is composed of the following subset Series:; GSE9712: Detection of genes differentially expressed in radioresistant tumors; GSE9713: Detection of genes differentially expressed in radioresistant and radiosensitive tumors before and after irradiation; GSE9714: Interferon response of radioresistant and radiosensitive human head&neck tumor cell lines Experiment Overall Design: Refer to individual Series

2008-06-16 | E-GEOD-9716 | biostudies-arrayexpress

Transcriptomes of 8 radiosensitive and 8 radioresistant colorectal cancer (CRC) patients

Project description:Transcriptomes of 8 radiosensitive and 8 radioresistant colorectal cancer (CRC) patients

| PRJNA776852 | ENA

DNA copy number alteration analysis of radioresistant and radiosensitive prostate cancer cell lines

Project description:Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. aCGH profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured and compared to normal DNA.

2019-10-11 | GSE134498 | GEO

Comparative analysis of gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines

Project description:Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. Gene expression profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured.

2019-10-11 | GSE134499 | GEO

Detection of genes differentially expressed in radioresistant and radiosensitive tumors before and after irradiation

Project description:Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors were profiled using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway Keywords: Pair-wise comparison of radiosensitive vs radioresistant tumors; time course of irradation response

2007-11-28 | GSE9713 | GEO

Gene Expression data from human radioresistant and radiosensitive Nasopharyngeal Carcinoma Cells

Project description:Most of the NPC patients suffer from local recurrences and distant metastases within 1.5 years after radiotherapy due to radioresistance. Distinct patterns of gene expression and signatures were found in NPC, and have been used to associate them with cell proliferation, apoptosis, invasion and metastasis, but few gene expression profiling studies have been focused on the tumor radioresistance.We used gene expression microarray analyses to identify the difference of mRNA in radioresistant NPC CNE2-IR cells and radiosensitive CNE2 cells. Radioresistant subclone of nasopharyngeal carcinoma CNE2-IR cell line was cultured and produced according to the experienment schedule to undergo five rounds of sublethal dose of irradiation (11 Gy), and the parent cell line CNE2 cell line sensitive to radiotherapy as the control

2013-12-10 | E-GEOD-48501 | biostudies-arrayexpress

MiRNA Expression data from human radioresistant and radiosensitive Nasopharyngeal Carcinoma Cells

Project description:Most of the NPC patients suffer from local recurrences and distant metastases within 1.5 years after radiotherapy due to radioresistance. Distinct patterns of miRNa expression and signatures were found in NPC, and have been used to associate them with cell proliferation, apoptosis, invasion and metastasis, but few miRNA expression profiling studies have been focused on the tumor radioresistance.We used miRNA expression microarray analyses to identify the difference of miRNA in radioresistant NPC CNE2-IR cells and radiosensitive CNE2 cells. Radioresistant subclone of nasopharyngeal carcinoma CNE2-IR cell line was cultured and produced according to the experienment schedule to undergo five rounds of sublethal dose of irradiation (11 Gy),and the parent cell line CNE2 sensitive to radiotherapy as the control

2013-12-10 | E-GEOD-48502 | biostudies-arrayexpress

MiRNA Expression data from human radioresistant and radiosensitive Nasopharyngeal Carcinoma Cells

2013-12-10 | GSE48502 | GEO

Gene Expression data from human radioresistant and radiosensitive Nasopharyngeal Carcinoma Cells

2013-12-10 | GSE48501 | GEO

MicroRNA expression difference between radiosensitive group and radioresistant group in atypical meningioma with gross total resection and adjuvant radiotherapy

Project description:For atypical meningiomas (AM), the combination of gross total resection (GTR) and adjuvant radiotherapy (ART) is still a controversial therapeutic strategy to improve prognosis. This study analysed the factors influencing the prognosis on AM patients treated with GTR+ART by investigating both clinical characteristics and the change in microRNA (miRNA) expression.Adult AM patients who were admitted to the Tiantan hospital from 2008 to 2015 and underwent GTR+ART were included. Patients who suffered recurrence within 3 years after operation were considered radioresistant, while the others were considered radiosensitive. Clinical characterizations were compared between these two groups. The miRNAs expression was detected via miRNA microarray in 10 patients, 5 from the radiosensitive group and 5 from the radioresistant group.No significant difference was found in the clinical characteristics. between radiosensitive and radioresistant patients. We found 7 significantly upregulated miRNAs and 7 significantly downregulated miRNAs in patients resistant to radiotherapy. The differentially expressed miRNAs were enriched mostly in the Fatty acid metabolic pathways (hsa00061, hsa01212) and TGF-β signalling pathway (hsa04350). For AM patients treated with GTR+ART, the changes in miRNA expression discovered in this study may be a potential predictor of individual sensitivity to adjuvant radiotherapy. Further research is needed regarding the predictive power and mechanism by which these miRNAs influence prognosis.

2020-01-23 | GSE144037 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data