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Total RNA sequencing in neuroprogenitors after SMG6 deletion

ABSTRACT: Identification of transcriptome changes in neuroprogenitor cells deficient for SMG6 mediated nonsence mediated mRNA decay with the aim to identify specific pathways or single genes causing the observed phenotype. Nestin-cre mediated Smg6 inactivation caused perinatal lethality and defective late cortical neurogenesis due to reduced renewal and survival of the cortical neuroprogenitor cells. However the Emx1-cre mediated deletion only in cortical and hippocampal progenitors did not cause comparable phenotypes. RNAseq identified mainly cell cycle and DNA damage response pathways modulating the transcriptome. FOXM1 was identified as possible upstream regulator of interneuron progenitor fate.

ORGANISM(S): Mus musculus

PROVIDER: GSE186964 | GEO | 2021/11/29

REPOSITORIES: GEO

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