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The Induction of Trained Immunity in the Pancreas Incites Anti-tumor Activity to Control Pancreatic Cancer Progression

ABSTRACT: Following treatment with WGP, we have observed an influx of immune cell populations into the pancreas over time. These cells have increased anti-tumor activities, which results in protection against pancreatic cancer growth. The study objective is to better understand the cell types involved in this process and the temporal nature of this influx. It is known that the immune influx peaks at day 7, so we are interested in the changes in the immune populations of the pancreas 3 days and 7 days following WGP treatment. To gain a more in depth analysis of the cell populations present in the pancreas after WGP treatment, a single cell RNA sequencing (scRNA-Seq) was performed on sorted CD45+ cells from PBS treated mice and mice treated with WGP 3 and 7 days prior.

ORGANISM(S): Mus musculus

PROVIDER: GSE187496 | GEO | 2022/01/04

REPOSITORIES: GEO

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