Myeloid progenitor cells lacking p53 exhibit delayed upregulation of Puma, prolonged survival after cytokine deprivation
Ontology highlight
ABSTRACT: We generated WT and p53-/- Factor Dependent Myeloid (FDM) cells and found that p53-/- cells were protected against IL-3 withdrawal. A survival advantage was also observed in untransformed p53-/- hematopoietic progenitor cells cultured in the presence or absence of cytokines. Array analysis was perfomed on RNA extracted from WT and p53-/- FDM cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE18770 | GEO | 2009/12/07
SECONDARY ACCESSION(S): PRJNA121619
REPOSITORIES: GEO
ACCESS DATA