Transcriptomics

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Myeloid progenitor cells lacking p53 exhibit delayed upregulation of Puma, prolonged survival after cytokine deprivation


ABSTRACT: We generated WT and p53-/- Factor Dependent Myeloid (FDM) cells and found that p53-/- cells were protected against IL-3 withdrawal. A survival advantage was also observed in untransformed p53-/- hematopoietic progenitor cells cultured in the presence or absence of cytokines. Array analysis was perfomed on RNA extracted from WT and p53-/- FDM cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE18770 | GEO | 2009/12/07

SECONDARY ACCESSION(S): PRJNA121619

REPOSITORIES: GEO

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