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CD19-CAR T cells undergo exhaustion epigenetic programming in patients with acute lymphoblastic leukemia

ABSTRACT: Zebley et al. show that CD8+ CD19-CAR T cells undergo genome-wide DNA methylation changes during an anti-tumor response in patients with B-cell acute lymphoblastic leukemia (ALL). Post-infusion CAR T cell differentiation involves acquisition of DNA methylation programs associated with effector function, repression of memory potential, and transition toward exhaustion.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188325 | GEO | 2021/11/08

REPOSITORIES: GEO

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CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia.

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