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Characterization and MicroRNA Levels of Serum-Derived Extracellular Vesicles in Hepatitis B Virus-Related diseases

ABSTRACT: Serum samples were collected from patients with CHB, DeCi and normal controls. We separated EVs from serum and identified them. MiRNAs from EVs were sequenced by NGS and analyzed to obtain differentially expressed miRNAs. Then we detected the expression level of candidate miRNAs from every single sample by qRT-PCR. The differences of serum EVs in patients with liver disease and 4 miRNAs with significantly different expression levels in EVs were determined. These serum EVs and miRNAs in EVs may be candidates for diagnosing and monitoring liver disease, or important therapeutic targets for the treatment of liver disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188328 | GEO | 2023/01/01

REPOSITORIES: GEO

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