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Chromatin accessibility profiling of human coronary arteries identifes disease regulatory variants

ABSTRACT: Coronary artery disease (CAD) is a complex inflammatory disease of the vessel wall and often leads to myocardial infarction. Genome-wide association studies (GWAS) have now identified over 200 genetic loci associated with CAD. The majority of CAD-associated variants are located in noncoding regions of the genome, many of which are predicted to regulate chromatin accessibility and gene expression. In this study, we performed ATAC-seq in human coronary artery patient samples to identify novel chromatin accessibility QTLs (caQTLs) and gain additional insights into CAD regulatory mechanisms in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188422 | GEO | 2022/01/24

REPOSITORIES: GEO

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