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Congenital T cell activation blocks transitional to follicular B cell maturation in humans

ABSTRACT: In patients with CTLA4 deficiency, CD40L-expressing T cells inhibit transitional to follicular B cell maturation in the T cell zone of lymph nodes through the induction of mTORC1 signaling in transitional B cells. We apply scRNA-seq to identify upregulation of PI3K, mTORC1, and oxidative phosphorylation pathways in patients with CTLA4 deficiency, and to characterize resolution of follicular block after treatment with abatacept.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188449 | GEO | 2021/11/10

REPOSITORIES: GEO

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