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Super-enhancer-associated TTC8 promotes neuroblastoma progression

ABSTRACT: We report a previously unrecognized role of super-enhancer-associated TTC8 in neuroblastoma. To explore TTC8-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the TTC8-knockdown SK-N-BE(2) cells in comparison to control group. We find that TTC8 activate the MAPK signaling pathway to promote the occurrence and development of neuroblastoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE188562 | GEO | 2022/08/29

REPOSITORIES: GEO

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