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Impact of fluoxetine treatment and folic acid supplementation on the mammary gland transcriptome during peak lactation

ABSTRACT: Lactation causes dramatic maternal calcemic adaptations where up to 10% of maternal bone density is mobilized for milk calcium. Serotonin plays a role in regulating this calcemic demand through alterations in DNA methylation. Selective serotonin reuptake inhibitors used to treat peripartum depression exacerbate this signaling. The first objective of this study was to determine the impact of fluoxetine, one of the most popular selective serotonin reuptake inhibitors, on the transcriptome of the mouse mammary gland during peak lactation. The second objective was to determine whether supplementation with folic acid, a well-known methyl donor, would mitigate the gene expression changes induced by fluoxetine.

ORGANISM(S): Mus musculus

PROVIDER: GSE188845 | GEO | 2021/11/22

REPOSITORIES: GEO

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