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Metabolic maturation of neonatal hearts driven by γ-linolenic acid in maternal milk [H3K27ac ChIP-seq]

ABSTRACT: The goal of this study was to compare the cistrome profile of H3K27ac (ChIP-seq) of perinatal hearts of cardiomyocyte-specific RXRab-deficient and WT mice, in order to identify genomic regions that are differentially activated by TF RXRa and RXRb.

ORGANISM(S): Mus musculus

PROVIDER: GSE188996 | GEO | 2023/02/15

REPOSITORIES: GEO

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Metabolic maturation of neonatal hearts driven by γ-linolenic acid in maternal milk [RXR ChIP-seq]

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Metabolic maturation of neonatal hearts driven by γ-linolenic acid in maternal milk [ATAC-seq]

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γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

Project description:The goal of this study was to compare the transcriptome profile (RNA-seq) of perinatal hearts of cardiomyocyte-specific RXRab-deficient (edKO) and WT mice, to identify genes that are controlled by the expression of the TF RXRa and RXRb.

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Metabolic maturation of neonatal hearts driven by γ-linolenic acid in maternal milk

Project description:Birth is the first metabolic challenge that cardiomyocytes need to overcome as they reshape their fuel preference from glucose to fatty acids (FA) to optimize energy production in postnatal life. This adaptation is partly triggered by drastic post-partum environmental changes, yet the molecular players responsible for orchestrating cardiomyocyte maturation remain unknown. Here, we discover that maternal metabolite γ-linolenic acid (GLA) support this transition. Specifically, colostrum GLA acts as an agonist for Retinoid X Receptors (RXR), a family of ligand-activated transcription factors expressed from embryonic life in cardiomyocytes. Mice lacking RXR in embryonic cardiomyocytes showed an aberrant chromatin landscape that prevented the induction of RXR-dependent FA metabolism genes (mtFAH signature). This results in a defective metabolic transition with blunted mitochondrial lipid-derived energy production and enhanced glucose consumption, which ultimately leads to perinatal lethal cardiac dysfunction. In vitro GLA supplementation in cardiomyocytes induced the expression of mtFAH signature in a RXR-dependent manner. Altogether, our study uncovers GLA/RXR axis as the fundamental mechanism by which maternal physiology commands metabolic functioning in perinatal hearts. This SuperSeries is composed of the SubSeries listed below.

2023-02-15 | GSE188998 | GEO

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homesotasis [Single Cells]

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Metabolic maturation of neonatal hearts driven by γ-linolenic acid in maternal milk [H3K27ac ChIP-seq]

Project description:Metabolic maturation of neonatal hearts driven by γ-linolenic acid in maternal milk [H3K27ac ChIP-seq]

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RXRs are required for neonatal expansion of the serosal macrophage pool and contribute to ovarian cancer progression

Project description:Distinct macrophage populations throughout the body display highly heterogeneous transcriptional and epigenetic programs. However, the regulation of chromatin accessibility of tissue-resident macrophages is poorly understood. In this study, we generated a data set for genome-wide transposase-accessible chromatin analysis (ATAC-seq) of large peritoneal macrophages in animals with myeloid-specific double deletion of the nuclear receptors RXRa and RXRb.

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