Transcriptomics

Dataset Information

0

Expression data of peritoneal carcinomatosis human cell lines co-treated with patient derived ascites and ligand inhibitor


ABSTRACT: Characterizations of ascites proteome from ovarian peritoneal carcinomatosis (PC) and gastric PC have demonstrated that ascites contains elevated pro-tumorigenic factors. Reasoning that the composition of ascitic fluid might offer insight into the memory of key biological events occurring intra-abdominally, we hypothesized that paracrine factors essential for survival and growth of peritoneal deposits are secreted into and circulate within ascitic fluid. Our data from cytokine array profile suggest that ascites contains biologically active ligands capable of supporting cellular functions of cancer cells. To decipher downstream signalling pathways activated in cancer cells when exposed to ascites, we performed gene expression analysis of Colo-205 cells upon exposure to PC ascites and ligand inhibitor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE189137 | GEO | 2022/02/22

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-02-22 | GSE189004 | GEO
2022-02-22 | GSE189168 | GEO
2008-01-31 | GSE8657 | GEO
| PRJNA781132 | ENA
| PRJNA781843 | ENA
2022-06-27 | GSE202454 | GEO
2019-02-12 | GSE126399 | GEO
2017-12-19 | GSE73064 | GEO
2024-05-29 | PXD045647 | Pride
2020-01-06 | E-MTAB-8140 | biostudies-arrayexpress