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CSF1R inhibition by PLX5622 affects multiple immune cell compartments with tissue-specific metabolic effects

ABSTRACT: We found that long-term CSF1R-inhibition by PLX5622 depleted tissue resident macrophages in different organs. This alteration resulted in a dual impact on glucose homeostasis with improved insulin sensitivity predominantly in the liver, combined with an insulin secretion defect in the islets of Langerhans. RNA-Seq analysis of islets of mice treated with PLX5622 compared to control mice hinted at a role of IL-1β in supporting insulin secretion,

ORGANISM(S): Mus musculus

PROVIDER: GSE189434 | GEO | 2023/06/29

REPOSITORIES: GEO

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