Early-life thermal stress mediates long-term alterations in hypothalamic microglia [RRBS]

ABSTRACT: We identified the microglial population in the chick anterior hypothalamus (AH) and showed that early-life thermal stress (on day 3 post-hatch) influences the inflammatory process in the AH. We described alterations in genome-wide CpG methylation profile of hypothalamic microglia between heat-conditioned and non-conditioned 10-day-old chicks prior LPS challenge. We suppose that changes in CpG DNA methylation might be involved in reprogramming microglial function.

ORGANISM(S): Gallus gallus

PROVIDER: GSE189564 | GEO | 2021/12/21

REPOSITORIES: GEO