Gene expression of leptin receptor (LEPR)+ bone marrow (BM) mesenchymal stem cells after lymphotoxin receptor (LT R) inhibition [LTbR]
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ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE189937 | GEO | 2021/12/04
REPOSITORIES: GEO
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Project description:Gene expression of leptin receptor (LEPR)+ bone marrow (BM) mesenchymal stem cells after lymphotoxin 훽 receptor (LT훽R) inhibition [LTbR]
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Project description:Leptin receptor (LEPR) identifies a subpopulation of hematopoietic stem cells (HSCs) with high repopulating potential. In this study, we demonstrated that LEPR-expressing HSCs while exhibiting significantly higher engrafting potential and self-renewing capacity in young mice showed early age-associated decline in these functions as compared to the LEPR- HSCs. LEPR+ HSCs have transcriptomic profiles significantly different from LEPR- HSCs in young mouse bone marrow, but middle-aged HSCs do not have distinct transcriptomic profiles based on LEPR status. The age-related phenotypes were associated with a proinflammatory transcriptomic profile at baseline in young LEPR+ HSCs, which was further exacerbated by age. In contrast, LEPR- HSCs did not show age-associated functional impairment at the ages tested. This suggested that subsets of HSCs are susceptible to age-related decline in function at varying ages and that LEPR+ HSCs are a potential target for early cellular therapeutic interventions in delaying the detrimental effects of aging in hematopoiesis.
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