Genomics

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ChIP-Seq analysis of ER binding sites in MCF7 breast cancer cells


ABSTRACT: Estrogen Receptor (ER) is a hormonal transcription factor that plays important roles in breast cancer. It functions primarily through binding to the regulatory regions of target genes containing the consensus ERE motifs. In order to identify ER target genes and re-define the ERE motifs we performed ChIP-Seq analysis of ER in MCF7 breast cancer cell line. Applying a novel computational algorithm named Hybrid Motif Sampler (HMS), specifically designed for TFBS motif discovery in ChIP-Seq data, we were able to detect an improved ERE motif and reveal intra-motif dependency especially in neighboring base pairs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19013 | GEO | 2010/02/01

SECONDARY ACCESSION(S): PRJNA121079

REPOSITORIES: GEO

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