Transcriptomics

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Tumor infiltrating CD8+ Tex cells dictate divergent survival outcomes in pre- vs post-menopausal ER+ breast cancer


ABSTRACT: We identify subsets of BC tumors infiltrated by CD8+ T cells with characteristic features of exhausted T cells (TEX). Tumors with abundant CD8+ TEX exhibit a distinct tumor microenvironment marked by amplified interferon-γ signaling related pathways and higher PD-L1 expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190169 | GEO | 2022/02/23

REPOSITORIES: GEO

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