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Genome-wide maps of chromatin openness in control and LMNA R527C mutant MSCs

ABSTRACT: We performed ATAC-seq to examine to chromatin of openness of coding genes in healthy control and LMNA R527C patient-derived MSCs. The reduction of LADs did not increase the accessibility of the promoters flanking coding genes. The genome wide analysis of ATAC-seq showed that openness of coding genes related chromatin was decreased in mutant MSCs.Thus, R527C mutant Lamin A led to dysfunction of LADs and dysregulation of gene transcription, probably, leading to slow down or arrest of cell proliferation and differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190195 | GEO | 2021/12/07

REPOSITORIES: GEO

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