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Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with rutin

ABSTRACT: Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using natural or synthetic agents would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of rutin, a bioactive phytochemical component derived from natural plants specifically ginkgo boliva, in targeting senescent cells via suppression of the SASP. This study demonstrates the efficacy of rutin as medicinal agent in controlling the influence of senescent human stromal cells and provides a strong rationale for its future use in aging intervention and geriatric medicine.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190279 | GEO | 2023/11/02

REPOSITORIES: GEO

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