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SRSF5 enhances the splicing of M gene by directly binding to M mRNA.

ABSTRACT: Influenza A viruses (IAVs) mRNA splicing represents an essential step in the viral life cycle. Here, we show that induction of SRSF5 by IAVs promotes viral replication by enhancing M mRNA splicing. To determine the motif in the M pre-mRNA targeted by SRSF5 RRM2 domain, the RNA eluted from co-precipitation of SRSF5–Flag from IAV-infected srsf5−/− HEK293 cells was subjected to deep sequencing analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190492 | GEO | 2021/12/10

REPOSITORIES: GEO

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Influenza virus infection induces widespread alterations of host cell splicing

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