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Targeting refractory mantle cell lymphoma for imaging and therapy using C-X-C chemokine receptor type 4 radioligands

ABSTRACT: CXCR4 is widely expressed in hematological malignancies, including MCL The Cancer Cell Line Encyclopedia (CCLE) showed relatively high levels of CXCR4 mRNA in hematological malignancies but had no MCL cell lines within its collection. To better assess the suitability of targeting CXCR4 in MCL, we screened 11 MCL cell lines for CXCR4 mRNA expression (Cancer Research Centre, CRC). For comparison, we profiled other lymphoma subtypes, including Burkitt (n=3), activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) (n=6), and germinal center B cell-like (GBC) DLBCL (n=14). On average, all lymphoma cell lines had high mRNA expression of CXCR4, though MCL cell lines had a higher expression of CXCR4 compared to GBC DLBCL (p<0.05). Hematological malignancy cell lines in both CRC and CCLE collections showed a significant increase in CXCR4 mRNA expression compared to a randomly selected sample of other cell lines in the CCLE (Supplementary Figure 6). The CXCR4 expression levels of the DLBCL and Burkitt lymphoma cell lines in the CCLE were in good agreement with our cell line RNA sequencing data when adjusted for batch effects.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190587 | GEO | 2022/01/12

REPOSITORIES: GEO

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