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TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190728 | GEO | 2022/09/19

REPOSITORIES: GEO

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TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [ultradeep]

Project description:Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic b-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-I interferon (IFN) mediated intracellular signalling. To study the role of TYK2 in human pancreatic b-cell development and response to IFNa, we generated TYK2 knockout human iPSCs and directed them into the pancreatic endocrine lineage. Unexpectedly, loss of TYK2 compromised the emergence of endocrine precursors by regulating KRAS expression, however, mature b-cell function was not affected. In the mature stem cell-derived islets, the loss or inhibition of TYK2 prevented IFNa-induced antigen processing and presentation, including MHC Class I expression, enhancing their survival against T-cell cytotoxicity. These results identify an unsuspected role for TYK2 on b-cell development and support TYK2 inhibition in adult b-cells as a potent therapeutic target to halt T1D progression.

2022-09-19 | GSE190727 | GEO

TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [tyk2_scRNAseq]

2022-09-19 | GSE190726 | GEO

TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [tyk2_bulkseq]

2022-09-19 | GSE190725 | GEO

TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha

Project description:TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha

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TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [tyk2_bulkseq]

Project description:TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [tyk2_bulkseq]

| PRJNA788276 | ENA

TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [ultradeep]

Project description:TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [ultradeep]

| PRJNA788277 | ENA

TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [tyk2_scRNAseq]

Project description:TYK2 regulates human pancreatic beta-cell development and its responses to interferon-alpha [tyk2_scRNAseq]

| PRJNA788275 | ENA

ISL1 controls pancreatic alpha cell fate and regulates beta cell differentiation and maturation

Project description:This SuperSeries is composed of the SubSeries listed below.

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The microRNA-200 family regulates pancreatic beta-cell survival in type 2 diabetes

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-05-06 | E-GEOD-58505 | biostudies-arrayexpress

An integrated multi-omics approach identifies the landscape of interferon-a-mediated responses of human pancreatic beta cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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