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A male-derived non-ribosomal peptide pheromone controls female schistosome development II

ABSTRACT: βAlanyl-tryptamine (BATT) is a peptide secreted by male S. mansoni upon pairing with a female parasite. Treatment of synthetic BATT on virgin females wihtout any pairing is sufficient to induce sexual development and egg depostiion.

ORGANISM(S): Schistosoma mansoni

PROVIDER: GSE191062 | GEO | 2021/12/23

REPOSITORIES: GEO

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A male-derived non-ribosomal peptide pheromone controls female schistosome development

Project description:gli1 is a gene in the male S. mansoni required for female sexual development. As a putative transcription factor, RNAseq comparing pairs with gli1 knocked-down or control males was performed to look for the genes which are trancriptionally regulated by gli1. sm-nrps was one of the essential candidate discovered in this analysis that has been characterized in the same publication, revealing a pheromone directed novel mechanism of female schistosome sexual development.

2021-10-04 | GSE184849 | GEO

A niche-derived non-ribosomal peptide triggers planarian sexual development.

Project description:Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche cells expressing a non-ribosomal peptide synthetase (nrps). Inhibiting nrps led to loss of female reproductive organs and testis hyperplasia. Mass spectrometry detected the dipeptide β-alanyl-tryptamine (BATT), which is associated with reproductive system development and requires nrps and a monoamine-transmitter-synthetic enzyme (AADC) for its production. Exogenous BATT rescued the reproductive defects after nrps or aadc inhibition, restoring fertility. Thus, a non-ribosomal, monoamine-derived peptide provided by niche cells acts as a critical signal to trigger planarian reproductive development. These findings reveal an unexpected function for monoamines in niche-germ cell signaling. Furthermore, given the recently reported role for BATT as a male-derived factor required for reproductive maturation of female schistosomes, these results have important implications for the evolution of parasitic flatworms and suggest a potential role for non-ribosomal peptides as signaling molecules in other organisms.

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A male-derived non-ribosomal peptide pheromone controls female schistosome development

Project description:A male-derived non-ribosomal peptide pheromone controls female schistosome development

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A male-derived nonribosomal peptide pheromone controls female schistosome development.

Project description:Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host. Studies dating back to the 1920s show that female schistosomes rely on constant physical contact with a male worm both to become and remain sexually mature; however, the molecular details governing this process remain elusive. Here, we uncover a nonribosomal peptide synthetase that is induced in male worms upon pairing with a female and find that it is essential for the ability of male worms to stimulate female development. We demonstrate that this enzyme generates β-alanyl-tryptamine that is released by paired male worms. Furthermore, synthetic β-alanyl-tryptamine can replace male worms to stimulate female sexual development and egg laying. These data reveal that peptide-based pheromone signaling controls female schistosome sexual maturation, suggesting avenues for therapeutic intervention and uncovering a role for nonribosomal peptides as metazoan signaling molecules.

| S-EPMC9058237 | biostudies-literature

A male-derived non-ribosomal peptide pheromone controls female schistosome development II

Project description:A male-derived non-ribosomal peptide pheromone controls female schistosome development II

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Transcription profiling of female Schistosoma mansoni from an unisexual infection of mice compared to worms from a mixed sex infection

Project description:In this study we describe the use of DNA microarrays to study the effect of sexual pairing of Schistosoma mansoni in the female gene expression. To accomplish this objective we compared female worms from unisexual infection with worms from mixed sex infection.

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Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, such as follistatin [Microarray]

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