Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SNP data from 20 bladder tumors

ABSTRACT: We present the first computational approach to reconstruct the sequence of copy number alterations driving carcinogenesis from the analysis of several tumor samples of a same patient. Applied to BAC array-CGH and SNP array data from bladder and breast cancers, this method proved highly valuable to establish the clonal relationships between primary tumors and recurrences and to identify the chromosome aberrations at the initiation of tumorigenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19189 | GEO | 2009/12/01

SECONDARY ACCESSION(S): PRJNA123745

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

SNP data from 20 bladder tumors

Project description:We present the first computational approach to reconstruct the sequence of copy number alterations driving carcinogenesis from the analysis of several tumor samples of a same patient. Applied to BAC array-CGH and SNP array data from bladder and breast cancers, this method proved highly valuable to establish the clonal relationships between primary tumors and recurrences and to identify the chromosome aberrations at the initiation of tumorigenesis. An algorithm was developed to reconstruct tumors lineage and the sequence of copy number alterations along tumorigenesis from the analysis of several samples from a same patient. The data here consist in Illumina SNP data from 20 bladder tumors. 15 of these tumors (REF1 to REF15) come from independent samples and were used to compute the frequencies of breakpoints at each location. The 5 other samples (S4_A, S4_B, S5_A, S5_B, and S5_C) are multiple tumors from 2 patients. They were used to reconstruct the sequence of chromosome aberrations along cancer development in these 2 patients.

2010-06-25 | E-GEOD-19189 | biostudies-arrayexpress

CGH data from 58 bladder tumors

2009-12-01 | GSE19193 | GEO

CGH data from 58 bladder tumors

Project description:We present the first computational approach to reconstruct the sequence of copy number alterations driving carcinogenesis from the analysis of several tumor samples of a same patient. Applied to BAC array-CGH and SNP array data from bladder and breast cancers, this method proved highly valuable to establish the clonal relationships between primary tumors and recurrences and to identify the chromosome aberrations at the initiation of tumorigenesis. Keywords: Comparative Genomic Hybridization An algorithm was developed to reconstruct tumors lineage and the sequence of copy number alterations along tumorigenesis from the analysis of several samples from a same patient. The data here consist in CGH data from 58 bladder tumors. 50 of these tumors come from independent samples and were used to compute the frequencies of breakpoints at each location. The 8 other samples (S1_A, S1_B, S2_A, S2_B, S3_A, S3_B, S3_C and S3_D) are multiple tumors from 3 patients. They were used to reconstruct the sequence of chromosome aberrations along cancer development in these 3 patients.

2010-05-19 | E-GEOD-19193 | biostudies-arrayexpress

Analysis of copy number profiles of several tumor samples of same patient reveals the successive steps in tumorigenesis

2010-06-25 | E-GEOD-19195 | biostudies-arrayexpress

Analysis of copy number profiles of several tumor samples of same patient reveals the successive steps in tumorigenesis

2009-12-01 | GSE19195 | GEO

Array CGH in TAR syndrome

Project description:The series represents the analysis data of four TAR syndrome patients by submegabase resolution BAC array. Keywords: array CGH

2007-01-07 | GSE5781 | GEO

CGH profiles of sporadic breast tumors

Project description:Genomic DNA from sporadic breast tumours was isolated and analysed using array CGH. The NKI 1MB BAC/PAC micro array was used to identify chromosomal aberrations of all tumours. Keywords: sporadic breast tumour, CGH

2010-07-05 | GSE9114 | GEO

CGH profiles of sporadic basal-like breast tumors

2010-10-26 | GSE22401 | GEO

Amplification and overexpression of E2F3 in human bladder cancer.

Project description:We demonstrate that, in human bladder cancer, amplification of the E2F3 gene, located at 6p22, is associated with overexpression of its encoded mRNA transcripts and high levels of expression of E2F3 protein. Immunohistochemical analyses of E2F3 protein levels have established that around one-third (33/101) of primary transitional cell carcinomas of the bladder overexpress nuclear E2F3 protein, with the proportion of tumours containing overexpressed nuclear E2F3 increasing with tumour stage and grade. When considered together with the established role of E2F3 in cell cycle progression, these results suggest that the E2F3 gene represents a candidate bladder cancer oncogene that is activated by DNA amplification and overexpression. Keywords: Tumour vs normal comparison, array CGH

2006-10-27 | GSE6123 | GEO

Array CGH analysis of 56 primary gastric cancers for elucidating prognostic biomarkers

Project description:Array CGH analysis was done with 56 primary gastric cancers to elucidate prognostic biomarkers on the BAC basis.

2010-08-10 | GSE15436 | GEO