Transcriptomics

Dataset Information

0

Differenatiation of mRNA expression in METTL3-depleted macrophages


ABSTRACT: N6-methyladenosine (m6A), the most prevalent internal messenger RNA modification, plays critical roles in diverse biological processes. To characterize the potential involvement of METTL3 in macrophage function, transcriptome sequencing (RNA-seq) was performed in human THP1-derived macrophages with METTL3 depletion. We identified 266 genes that were differentially expressed in METTL3-depleted macrophages (≥ 1.5-fold change, P < 0.05), among which 44% (118 genes) were downregulated and 56% (148 genes) were upregulated. Notably, M2 macrophages activation-associated genes were robustly enhanced in METTL3-depleted macrophages. This study highlights the critical roles of m6A on regulation macrophages homeostasis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE192533 | GEO | 2023/10/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-09-24 | PXD036032 | Pride
2023-07-12 | E-MTAB-11570 | biostudies-arrayexpress
2014-01-06 | E-GEOD-46878 | biostudies-arrayexpress
2023-10-06 | GSE193340 | GEO
2024-09-20 | PXD050565 | Pride
2023-03-10 | PXD036773 | Pride
2024-02-01 | PXD048886 | Pride
2014-10-16 | E-GEOD-52662 | biostudies-arrayexpress
2016-03-24 | E-GEOD-79523 | biostudies-arrayexpress
2021-04-30 | GSE162248 | GEO