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Large scale transposon co-option in the Caenorhabditis germline regulatory network

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Caenorhabditis elegans Caenorhabditis briggsae

PROVIDER: GSE192540 | GEO | 2021/12/26

REPOSITORIES: GEO

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Large scale transposon co-option in the Caenorhabditis germline regulatory network [longCapSeq]

Project description:The movement of repetitive elements in the germline creates widespread genomic alterations and pressure for resolution. Here we show that the Caenorhabditis clade took advantage of two transposon expansions by integrating hundreds of elements into its germline transcriptional network. We find that about one-third of C. elegans germline-specific promoters have been co-opted from CERP2 and CELE2 MITE elements and are regulated by HIM-17, a THAP domain-containing transcription factor related to a transposase. An ancestral CERP2 expansion took place in the common Caenorhabditis ancestor, concurrently with mutations in HIM-17 fixed by positive selection, whereas CELE2 expanded only in C. elegans. Through comparative analyses in C. briggsae, we find conservation as well as species-specific CERP2 co-option. Our work reveals the emergence of a novel transcriptional network driven by TE co-option and its impact on regulatory evolution.

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Large scale transposon co-option in the Caenorhabditis germline regulatory network [RNA-Seq]

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Large scale transposon co-option in the Caenorhabditis germline regulatory network [ChIP-Seq]

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Widespread transposon co-option in the <i>Caenorhabditis</i> germline regulatory network.

Project description:The movement of selfish DNA elements can lead to widespread genomic alterations with potential to create novel functions. We show that transposon expansions in Caenorhabditis nematodes led to extensive rewiring of germline transcriptional regulation. We find that about one-third of Caenorhabditis elegans germline-specific promoters have been co-opted from two related miniature inverted repeat transposable elements (TEs), CERP2 and CELE2. These promoters are regulated by HIM-17, a THAP domain-containing transcription factor related to a transposase. Expansion of CERP2 occurred before radiation of the Caenorhabditis genus, as did fixation of mutations in HIM-17 through positive selection, whereas CELE2 expanded only in C. elegans. Through comparative analyses in Caenorhabditis briggsae, we find not only evolutionary conservation of most CERP2 co-opted promoters but also a substantial fraction that are species-specific. Our work reveals the emergence and evolutionary conservation of a novel transcriptional network driven by TE co-option with a major impact on regulatory evolution.

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Large scale transposon co-option in the Caenorhabditis germline regulatory network

Project description:Large scale transposon co-option in the Caenorhabditis germline regulatory network

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Large scale transposon co-option in the Caenorhabditis germline regulatory network [longCapSeq]

Project description:Large scale transposon co-option in the Caenorhabditis germline regulatory network [longCapSeq]

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Large scale transposon co-option in the Caenorhabditis germline regulatory network [ChIP-Seq]

Project description:Large scale transposon co-option in the Caenorhabditis germline regulatory network [ChIP-Seq]

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Large scale transposon co-option in the Caenorhabditis germline regulatory network [RNA-Seq]

Project description:Large scale transposon co-option in the Caenorhabditis germline regulatory network [RNA-Seq]